It is important to remember that a given individual with WAGR syndrome may or may not have or develop the condition listed below. |
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Seizure disorders are common in children and adults with WAGR syndrome. Pancreatitis is also associated with WAGR syndrome. Although valproaic acid (Depakote, Depokene, Epilum) is frequently prescribed for the treatment of seizure disorders, it is possible that it may raise the risk of pancreatitis in these individuals.
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Avoid use of valporic acid
Valproic acid is known to cause rare cases of life-threatening pancreatitis (inflammation of the pancreas). Pancreatitis can come on suddenly and symptoms may start even after you have been taking valproic acid for several years.
J Gastroenterol. 2007 Jan;42(1):39-48. Epub 2007 Feb 16.
Valproic acid-induced pancreatitis: 16 new cases and a review of the literature.
Gerstner T, Büsing D, Bell N, Longin E, Kasper JM, Klostermann W, Hebing B, Hanefeld F, Eckel U, Hoffmann R, Bettendorf U, Weidner B, Wiemer-Kruel A, Brockmann K, Neumann FW, Sandrieser T, Wolff M, König S. University Children's Hospital Mannheim, Neuropediatric Unit, Theodor-Kutzer-Ufer 1-3, Mannheim, Germany.
Pediatrics. 2006 Oct;118(4):1660-3.
Links
The spectrum of valproic acid-associated pancreatitis.Werlin SL, Fish DL.Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA. swerlin@mcw.edu
J Child Neurol. 2004 Jul;19(7):498-502.
Links
Valproic acid-induced pancreatitis in childhood epilepsy: case series and review.
Sinclair DB, Berg M, Breault R.Division of Pediatric Neurology, 2C3 Walter MacKenzie Health Sciences Centre, University of Alberta, Edmonton, AB T6G 2R7, Canada.
bsinclai@cha.ab.ca
Pediatr Neurol. 2003 Feb;28(2):145-8.
Links
Acute pancreatitis in children from Valproic acid: case series and review.
Grauso-Eby NL, Goldfarb O, Feldman-Winter LB, McAbee GN.Department of Pediatrics, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford, New Jersey 08084, USA. |
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