It is important to remember that a given individual with WAGR syndrome may or may not have or develop the condition listed below.
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Seizures and WAGR Syndrome
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Seizure disorders are common in children and adults with WAGR syndrome. Pancreatitis is also associated with WAGR syndrome. Although Valproic Acid (depakote/depokene, epilum) is frequently prescribed for the treatment of seizure disorders, it is possible that it may raise the risk of pancreatitis in these individuals.
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REVIEW ARTICLE
Bernard V. Fischbach, MD*, Kelly L. Trout, RN, BSN, Julia Lewis, MD*, Catherine A. Luis and Mohammed Sika, PhD*
* Department of Medicine, Division of Nephrology, Vanderbilt Medical Center, Nashville, Tennessee
PEDIATRICS Vol. 116 No. 4 October 2005, pp. 984-988 (doi:10.1542/peds.2004-0467)
TABLE 2.
Nonclassical Clinical Findings in WAGR Syndrome in Study Participants (N = 54)
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Avoid use of valporic acid
Valproic acid is known to cause rare cases of life-threatening pancreatitis (inflammation of the pancreas). Pancreatitis can come on suddenly and symptoms may start even after you have been taking valproic acid for several years.
J Gastroenterol. 2007 Jan;42(1):39-48. Epub 2007 Feb 16.
Valproic acid-induced pancreatitis: 16 new cases and a review of the literature.
Gerstner T, Büsing D, Bell N, Longin E, Kasper JM, Klostermann W, Hebing B, Hanefeld F, Eckel U, Hoffmann R, Bettendorf U, Weidner B, Wiemer-Kruel A, Brockmann K, Neumann FW, Sandrieser T, Wolff M, König S. University Children's Hospital Mannheim, Neuropediatric Unit, Theodor-Kutzer-Ufer 1-3, Mannheim, Germany.
Pediatrics. 2006 Oct;118(4):1660-3.
Links
The spectrum of valproic acid-associated pancreatitis.Werlin SL, Fish DL.Department of Pediatrics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA. swerlin@mcw.edu
J Child Neurol. 2004 Jul;19(7):498-502.
Links
Valproic acid-induced pancreatitis in childhood epilepsy: case series and review.
Sinclair DB, Berg M, Breault R.Division of Pediatric Neurology, 2C3 Walter MacKenzie Health Sciences Centre, University of Alberta, Edmonton, AB T6G 2R7, Canada.
bsinclai@cha.ab.ca
Pediatr Neurol. 2003 Feb;28(2):145-8.
Links
Acute pancreatitis in children from Valproic acid: case series and review.
Grauso-Eby NL, Goldfarb O, Feldman-Winter LB, McAbee GN.Department of Pediatrics, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford, New Jersey 08084, USA.
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